Transforming growth factor-β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis.
Identifieur interne : 004A30 ( Main/Exploration ); précédent : 004A29; suivant : 004A31Transforming growth factor-β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis.
Auteurs : Alexander Yaw Debrah [Ghana] ; Linda Batsa ; Anna Albers ; Sabine Mand ; Mohammad Reza Toliat ; Peter Nürnberg ; Ohene Adjei ; Achim Hoerauf ; Kenneth PfarrSource :
- Human immunology [ 1879-1166 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe (sang), Facteur de croissance transformant bêta-1 (génétique), Femelle, Filariose lymphatique (génétique), Filariose lymphatique (immunologie), Filariose lymphatique (physiopathologie), Filariose lymphatique (sang), Ghana, Génotype, Humains, Microfilaria (métabolisme), Mutation (génétique), Mâle, Polymorphisme génétique, Prédisposition génétique à une maladie, Sujet âgé, Wuchereria bancrofti (pathogénicité), Wuchereria bancrofti (physiologie), Études d'associations génétiques, Évolution de la maladie.
- MESH :
- génétique : Facteur de croissance transformant bêta-1, Filariose lymphatique, Mutation.
- immunologie : Filariose lymphatique.
- métabolisme : Microfilaria.
- pathogénicité : Wuchereria bancrofti.
- physiologie : Wuchereria bancrofti.
- physiopathologie : Filariose lymphatique.
- sang : Antigènes d'helminthe, Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Ghana, Génotype, Humains, Mâle, Polymorphisme génétique, Prédisposition génétique à une maladie, Sujet âgé, Études d'associations génétiques, Évolution de la maladie.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antigens, Helminth (blood), Disease Progression, Elephantiasis, Filarial (blood), Elephantiasis, Filarial (genetics), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (physiopathology), Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Ghana, Humans, Male, Microfilariae (metabolism), Middle Aged, Mutation (genetics), Polymorphism, Genetic, Transforming Growth Factor beta1 (genetics), Wuchereria bancrofti (pathogenicity), Wuchereria bancrofti (physiology).
- MESH :
- chemical , blood : Antigens, Helminth.
- blood : Elephantiasis, Filarial.
- genetics : Elephantiasis, Filarial, Mutation, Transforming Growth Factor beta1.
- immunology : Elephantiasis, Filarial.
- metabolism : Microfilariae.
- pathogenicity : Wuchereria bancrofti.
- physiology : Wuchereria bancrofti.
- physiopathology : Elephantiasis, Filarial.
- Adolescent, Adult, Aged, Animals, Disease Progression, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Ghana, Humans, Male, Middle Aged, Polymorphism, Genetic.
Abstract
Antigen testing and ultrasound detection have shown that many persons are infected with Wuchereria bancrofti even though they do not have microfilariae (Mf) in the blood. To ascertain the role of human host immunogenetics on the lack of circulating Mf in the blood, 152 lymphatic filariasis (LF)-infected patients comprising 118 patients with microfilaremic (Mf+, patent) infection and 34 patients with latent (Mf-, antigen-positive) infection were recruited and genotyped for association of single nucleotide polymorphisms of TGF-β1 and differential Mf load and/or lack of Mf in the blood from infected persons in Ghana. An association was found between the TGF-β1 Leu10Pro variant and lack of Mf in the blood. Patients with latent infection had a higher frequency of the Leu/Leu genotype than patients with patent infection (p = 0.03). Secondary analysis revealed an association among the three possible Leu10Pro genotypes and different Mf loads in the blood. In conclusion, the differential Mf loads and the lack of Mf in the blood of patients is likely to have a genetic basis. Because the adult worms are responsible for pathology, these results underscore the need for a review of using only Mf detection in blood smears for diagnosis of LF infection in endemic areas. This information is also important for the mapping and surveillance activities of national and global programs for elimination of LF.
DOI: 10.1016/j.humimm.2011.07.305
PubMed: 21843572
Affiliations:
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uniqKey="Albers A" first="Anna" last="Albers">Anna Albers</name></author><author><name sortKey="Mand, Sabine" sort="Mand, Sabine" uniqKey="Mand S" first="Sabine" last="Mand">Sabine Mand</name></author><author><name sortKey="Toliat, Mohammad Reza" sort="Toliat, Mohammad Reza" uniqKey="Toliat M" first="Mohammad Reza" last="Toliat">Mohammad Reza Toliat</name></author><author><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name></author><author><name sortKey="Adjei, Ohene" sort="Adjei, Ohene" uniqKey="Adjei O" first="Ohene" last="Adjei">Ohene Adjei</name></author><author><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name></author><author><name sortKey="Pfarr, Kenneth" sort="Pfarr, Kenneth" uniqKey="Pfarr K" first="Kenneth" last="Pfarr">Kenneth Pfarr</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date 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variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis.</title><author><name sortKey="Debrah, Alexander Yaw" sort="Debrah, Alexander Yaw" uniqKey="Debrah A" first="Alexander Yaw" last="Debrah">Alexander Yaw Debrah</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Batsa, Linda" sort="Batsa, Linda" uniqKey="Batsa L" first="Linda" last="Batsa">Linda Batsa</name></author><author><name sortKey="Albers, Anna" sort="Albers, Anna" uniqKey="Albers A" first="Anna" last="Albers">Anna Albers</name></author><author><name sortKey="Mand, Sabine" sort="Mand, Sabine" uniqKey="Mand S" first="Sabine" last="Mand">Sabine Mand</name></author><author><name sortKey="Toliat, Mohammad Reza" sort="Toliat, Mohammad Reza" uniqKey="Toliat M" first="Mohammad Reza" last="Toliat">Mohammad Reza Toliat</name></author><author><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name></author><author><name sortKey="Adjei, Ohene" sort="Adjei, Ohene" uniqKey="Adjei O" first="Ohene" last="Adjei">Ohene Adjei</name></author><author><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name></author><author><name sortKey="Pfarr, Kenneth" sort="Pfarr, Kenneth" uniqKey="Pfarr K" first="Kenneth" last="Pfarr">Kenneth Pfarr</name></author></analytic><series><title level="j">Human immunology</title><idno type="eISSN">1879-1166</idno><imprint><date when="2011" 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scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Mutation</term><term>Transforming Growth Factor beta1</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance transformant bêta-1</term><term>Filariose lymphatique</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Microfilaria</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" 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Aged</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Ghana</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Polymorphisme génétique</term><term>Prédisposition génétique à une maladie</term><term>Sujet âgé</term><term>Études d'associations génétiques</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Antigen testing and ultrasound detection have shown that many persons are infected with Wuchereria bancrofti even though they do not have microfilariae (Mf) in the blood. To ascertain the role of human host immunogenetics on the lack of circulating Mf in the blood, 152 lymphatic filariasis (LF)-infected patients comprising 118 patients with microfilaremic (Mf+, patent) infection and 34 patients with latent (Mf-, antigen-positive) infection were recruited and genotyped for association of single nucleotide polymorphisms of TGF-β1 and differential Mf load and/or lack of Mf in the blood from infected persons in Ghana. An association was found between the TGF-β1 Leu10Pro variant and lack of Mf in the blood. Patients with latent infection had a higher frequency of the Leu/Leu genotype than patients with patent infection (p = 0.03). Secondary analysis revealed an association among the three possible Leu10Pro genotypes and different Mf loads in the blood. In conclusion, the differential Mf loads and the lack of Mf in the blood of patients is likely to have a genetic basis. Because the adult worms are responsible for pathology, these results underscore the need for a review of using only Mf detection in blood smears for diagnosis of LF infection in endemic areas. This information is also important for the mapping and surveillance activities of national and global programs for elimination of LF.</div></front></TEI><affiliations><list><country><li>Ghana</li></country></list><tree><noCountry><name sortKey="Adjei, Ohene" sort="Adjei, Ohene" uniqKey="Adjei O" first="Ohene" last="Adjei">Ohene Adjei</name><name sortKey="Albers, Anna" sort="Albers, Anna" uniqKey="Albers A" first="Anna" last="Albers">Anna Albers</name><name sortKey="Batsa, Linda" sort="Batsa, Linda" uniqKey="Batsa L" first="Linda" last="Batsa">Linda Batsa</name><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><name sortKey="Mand, Sabine" sort="Mand, Sabine" uniqKey="Mand S" first="Sabine" last="Mand">Sabine Mand</name><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name><name sortKey="Pfarr, Kenneth" sort="Pfarr, Kenneth" uniqKey="Pfarr K" first="Kenneth" last="Pfarr">Kenneth Pfarr</name><name sortKey="Toliat, Mohammad Reza" sort="Toliat, Mohammad Reza" uniqKey="Toliat M" first="Mohammad Reza" last="Toliat">Mohammad Reza Toliat</name></noCountry><country name="Ghana"><noRegion><name sortKey="Debrah, Alexander Yaw" sort="Debrah, Alexander Yaw" uniqKey="Debrah A" first="Alexander Yaw" last="Debrah">Alexander Yaw Debrah</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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